肠道微生态与肝病专题服装服装服装服装服装服装论坛t.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.net暨2021（第七届）肠道微生态与安康国际钻研会会前会

人体肠道内寄生着大批的微生物，并对人体的代谢、免疫、发育等多种心理进程阐扬主要的调理感化。在多种慢性肝病的成长进程中都伴跟着肠道菌群的转变。一方面，肝脏疾病的产生能够影响肠道菌群的构成。比方，乙肝病毒的沾染能够延缓肠道菌群的定植和成熟。另外一方面，肠道菌群也能反过去影响肝脏疾病的成长。比方，当肠道菌群失衡时，肠道的通透性产生转变，肠道菌群能向肝脏内移位，按捺肝脏免疫，倒霉于乙肝病毒的断根。另外，肠道菌群在本身免疫性肝病、代谢性肝病、酒精性肝病的产生成长进程中都阐扬这主要的感化。粪菌移植能够增进慢性乙型肝炎患者HBeAg抗原的降落，还可用于医治肝性脑病。

是以，本服装服装服装服装服装服装论坛t.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.net特邀华中科技大学从属协和病院王俊忠博士，环绕”肠道微生态与肝病“的最新前沿研讨停止出色分享！

Abstract

Approximately a trillion microbial cells colonize the mammalian intestine; these are collectively termed gut microbiota. Gut microbiota play a critical role in many physiological and pathological processes, influencing host immunity and metabolism. Gut dysbiosis is related to not only intestinal but also extra-intestinal diseases, including nervous system, respiratory, cardiovascular system, and liver diseases.

The liver is the largest internal organ and gland in the human body, which receives blood both from the portal vein and hepatic artery. Therefore, the liver is exposed to gut microbes as well as their metabolites and products. Previous studies showed that live commensal bacteria can be sampled by intestinal dendritic cells (DC) and transferred to the liver through the lymphatic route or portal vein. In healthy mice, the liver can act as a second firewall in which Kupffer cells can capture and clean commensal bacteria from the systemic vasculature. The healthy liver can maintain sterility by removing not only live commensal bacteria but also microbial metabolites and products.

Gut microbiota dysbiosis is related to chronic liver diseases, including alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune liver disease, chronic hepatitis B and C, liver cirrhosis, and hepatocellular carcinoma (HCC). In mice, gut microbiota depletion was found to impair the HBV-specific T cell response and prolong HBV infection. In patients with hepatitis B-related cirrhosis, the gut microbiota community and metabolism mediated by the gut microbiota was significantly changed when compared with healthy controls. Reconstitution of the gut microbiota using fecal microbiota transplantation (FMT) facilitated hepatitis B virus e-antigen (HBeAg) clearance in patients with HBeAg-positive chronic hepatitis B after long-term antiviral therapy. FMT is also a potent therapy strategy for hepatic encephalopathy.