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肠道微生态与肝病专题服装服装服装服装服装服装论坛t.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.net暨2021(第七届)肠道微生态与安康国际钻研会会前会

直播日期 2021/10/19 14:00

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肠道微生态与肝病专题服装服装服装服装服装服装论坛t.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.net暨2021(第七届)肠道微生态与安康国际钻研会会前会

人体肠道内寄生着大批的微生物,并对人体的代谢、免疫、发育等多种心理进程阐扬主要的调理感化。在多种慢性肝病的成长进程中都伴跟着肠道菌群的转变。一方面,肝脏疾病的产生能够影响肠道菌群的构成。比方,乙肝病毒的沾染能够延缓肠道菌群的定植和成熟。另外一方面,肠道菌群也能反过去影响肝脏疾病的成长。比方,当肠道菌群失衡时,肠道的通透性产生转变,肠道菌群能向肝脏内移位,按捺肝脏免疫,倒霉于乙肝病毒的断根。另外,肠道菌群在本身免疫性肝病、代谢性肝病、酒精性肝病的产生成长进程中都阐扬这主要的感化。粪菌移植能够增进慢性乙型肝炎患者HBeAg抗原的降落,还可用于医治肝性脑病。

是以,本服装服装服装服装服装服装论坛t.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.nett.vhao.net特邀华中科技大学从属协和病院王俊忠博士,环绕”肠道微生态与肝病“的最新前沿研讨停止出色分享!

Abstract


Approximately a trillion microbial cells colonize the mammalian intestine; these are collectively termed gut microbiota. Gut microbiota play a critical role in many physiological and pathological processes, influencing host immunity and metabolism. Gut dysbiosis is related to not only intestinal but also extra-intestinal diseases, including nervous system, respiratory, cardiovascular system, and liver diseases.

The liver is the largest internal organ and gland in the human body, which receives blood both from the portal vein and hepatic artery. Therefore, the liver is exposed to gut microbes as well as their metabolites and products. Previous studies showed that live commensal bacteria can be sampled by intestinal dendritic cells (DC) and transferred to the liver through the lymphatic route or portal vein. In healthy mice, the liver can act as a second firewall in which Kupffer cells can capture and clean commensal bacteria from the systemic vasculature. The healthy liver can maintain sterility by removing not only live commensal bacteria but also microbial metabolites and products.

Gut microbiota dysbiosis is related to chronic liver diseases, including alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune liver disease, chronic hepatitis B and C, liver cirrhosis, and hepatocellular carcinoma (HCC). In mice, gut microbiota depletion was found to impair the HBV-specific T cell response and prolong HBV infection. In patients with hepatitis B-related cirrhosis, the gut microbiota community and metabolism mediated by the gut microbiota was significantly changed when compared with healthy controls. Reconstitution of the gut microbiota using fecal microbiota transplantation (FMT) facilitated hepatitis B virus e-antigen (HBeAg) clearance in patients with HBeAg-positive chronic hepatitis B after long-term antiviral therapy. FMT is also a potent therapy strategy for hepatic encephalopathy.

佳宾简介

王俊忠博士(华中科技大学从属协和病院)

王俊忠博士毕业于华中科技大学,曾在德国杜伊斯堡-埃森大学和美国东南大学处置博士后和拜候学者研讨任务。对慢性病毒性肝炎、肝软化、重型肝炎、本身免疫性肝病、代谢性肝病、血吸虫性肝病等的诊治具备丰硕的临床经历,特别是对病毒性肝炎的病发机制和免疫调理医治有深切的研讨,对肠道微生态在病毒性肝炎的病发机制中的研讨有怪异的看法,并展开了操纵调理肠道微生态医治肝性脑病的临床研讨、操纵肠道微生态及肠道功效的转变展望肝衰竭患者的临床转归及终局。获湖北省科技前进奖一等奖1项、教导部科技前进二等奖1项。掌管国度天然迷信基金1项,作为主要成员到场国度沾抱病防治严重专项课题、中国-德国国际科技协作与交换严重课题、国度天然迷信基金等课题十余项。颁发论文30余篇,到场编写天下大学本科生及研讨生课本《沾抱病学》、《王宝恩肝脏病学》、《新发沾抱病学》等多部专著。

Biosketch

Dr. Junzhong Wang got his Medical Doctor degree from Huazhong University of Science and Technology, and worked as postdoctoral fellow in University of Duisburg-Essen in German and Northwestern University in US. Dr. Junzhong Wang is an expert in the field of hepatology, is proficient in diagnosis and treatment of many liver diseases, including viral hepatitis, liver cirrhosis, liver failure, autoimmune liver diseases, metabolic liver diseases, etc. Dr. Junzhong Wang also investigates the immune response and immunotherapy of the viral hepatitis, the cross-talk of the gut microbiota and immune cells in liver. His research indicated that HBV infection can delay the maturation of gut microbiota, and microbiota played a protective role for the antiviral immunity in liver. In addition, Dr. Junzhong Wang have carried out the clinical research to develop the therapy strategy for hepatic encephalopathy based on fecal microbiota transplantation.

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